Gene expression microarray analysis of cardiomyocytes with a disrupted circadian clock: from raw data to biological interpretation

Will be presented March 19, 2008 by Peter Roberts, Ph.D.

The presentation is an alternate analysis of gene expression microarray data recently deposited in the Gene Expression Omnibus (GEO accession: GSE10045) and described by Bray et al. (Am J Physiol Heart Circ Physiol 294: H1036-H1047, 2008). Illumina Mouse Ref-6 Beadchips were used to generate the gene expression data. Samples from atria and ventricles of wild-type mice and cardiomyocyte-specific circadian clock mutant (CCM) mice are compared, to see the effect on normal diurnal gene expression patterns. Statistically significant differentially expressed genes will be identified. The significant biological functions associated with those genes will be charcterized from gene ontology and pathway analysis.
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The GeneSifter Data Center is an online resource providing access to diverse sets of microarray data, supplemented with side-by-side tutorials. The site already contains a number of data sets from previous webinars focused on other fields of study. It is free for examination and use, and requires only brief registration at www.genesifter.com/dc.