Microarray Analysis of Gene Expression in Huntington's Disease Peripheral Blood - a Platform Comparison

The archived copy of "Microarray Analysis of Gene Expression in Huntington's Disease Peripheral Blood - a Platform Comparison," by N. Eric Olson, PhD, an online webinar examining gene expression data from both the Affymetrix GeneChip® and the GE CodeLink® microarray platforms, is now available for viewing.

The presentation describes an alternative analysis of datasets available from the Gene Expression Omnibus, accession numbers GSE1751 and GSE1767. Both datasets were originally reported in the article "Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease," (Boroveki et al 2005), published in the Proceedings of the National Academy of Sciences.

The data examines gene expression in human blood from symptomatic HD patients, and demonstrates that this neurodegenerative disorder results in significant differential gene expression in peripheral blood. Specific pathways and molecular functions will be identified and discussed during the webinar.

Data was collected using both GeneChip and CodeLink arrays, providing a useful opportunity to examine the differences in array data between platforms, and to evaluate and compare their performance.

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